Table 1.

Activity of all HDACi in the human HDAC1 and HDAC8 inhibition tests

	SAHA	5a	5b	5c	5d	5e	5f	5g	6a	6b	6c	6d	6e	6f	6g
HDAC 1	72 ± 2	31 ± 4	10 ± 3	8 ± 2	13 ± 4	8 ± 2	15 ± 3	75 ± 5	18 ± 3	9 ± 1	NS	NS	NS	NS	10 ± 1
HDAC 8	NS	12 ± 6	NS	NS	NS	NS	NS	NS	12 ± 2	12 ± 2	NS	26 ± 3	NS	NS	13 ± 2

The values given represent the percentage by which the HDAC activity was inhibited by a 0.50 μM HDACi treatment.

All of the assays were repeated at least three times.

When the inhibition capacity was less than 5%, NS (meaning no significant inhibition) was assigned.