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Knockdown of Mnt by stable RNAi accelerates cell proliferation. (A) Morphological changes induced by MntRNAi expression in MEFs, BALB/c-3T3 cells, and c-myc−/− HO.15 fibroblasts are shown. (B) Acceleration of cell proliferation by ablation of Mnt is independent of c-myc but requires E2f1. Growth rates of the indicated MntRNAi-expressing cells were compared to GFP-only expressing fibroblasts.
