Figure 3.

Images of mice injected with ¹¹¹In-loaded liposomes. (A) SPECT and (C) ex vivo phosphor imaging showed no focal, aortic arch hot spots in ApoE −/− mice injected with the nIgG probe, whereas all ApoE −/− mice injected with the LOX-1 probe revealed hot spots in the aortic arch ((B) includes sagittal, coronal, and transverse planes), confirmed by (D) ex vivo phosphor imaging. Sudan IV staining demonstrated comparable plaque distribution pattern for the (E and F) two groups. Reproduced with permission from [47].