Table 3.
Geometric means of serum 25(OH)D by genotype
| genotype | n | Geometric mean* 25(OH)D nmol/L (95% CI) |
p for trend |
Variance explained by the model, % † |
Variance explained by genotype, % ‡ |
|
|---|---|---|---|---|---|---|
| CYP2R1 | ||||||
| rs10741657 | GG | 253 | 64.9 (62.9–67.0) | 0.02 | 11.1 | 1.0 |
| GA | 192 | 67.6 (65.3–70.0) | ||||
| AA | 50 | 70.0 (65.3–75.3) | ||||
| rs12794714 | GG | 197 | 69.2 (66.8–71.7) | <0.001 | 13.3 | 3.1 |
| GA | 242 | 66.0 (64.0–68.2) | ||||
| AA | 58 | 58.6 (54.9–62.5) | ||||
| rs1993116 | CC | 248 | 64.6 (62.6–66.7) | 0.04 | 11.4 | 0.8 |
| CT | 201 | 67.8 (65.5–70.2) | ||||
| TT | 42 | 68.5 (63.5–73.9) | ||||
| CYP3A4 | ||||||
| rs2242480 | CC | 258 | 68.5 (66.4–70.6) | 0.008 | 11.5 | 1.3 |
| CT | 199 | 63.9 (61.7–66.2) | ||||
| TT | 40 | 64.5 (59.6–69.7) | ||||
| GC | ||||||
| rs4588 | CC | 267 | 68.7 (66.7–70.8) | <0.001 | 13.3 | 3.7 |
| CA | 173 | 64.3 (61.9–66.8) | ||||
| AA | 39 | 57.2 (52.8–61.9) | ||||
| rs7041 | TT | 226 | 64.0 (61.9–66.1) | 0.003 | 12.0 | 1.6 |
| TG | 212 | 67.7 (65.4–70.0) | ||||
| GG | 53 | 70.6 (65.9–75.6) | ||||
| rs2298849 | TT | 176 | 63.9 (61.6–66.3) | 0.001 | 12.7 | 2.1 |
| TC | 237 | 66.1 (64.0–68.3) | ||||
| CC | 77 | 72.2 (68.2–76.4) | ||||
| rs16847015 | CC | 275 | 64.1 (62.2–66.0) | 0.002 | 12.8 | 1.9 |
| CA | 175 | 68.5 (66.0–71.1) | ||||
| AA | 39 | 70.8 (65.5–76.6) |
Abbreviations: CYP2R1 = cytochrome P450 2R1, CYP3A4 = cytochrome P450 3A4, GC = group complement (vitamin D binding protein), rs = refSNP or reference single nucleotide polymorphism.
25(OH)D concentrations are multivariate adjusted for: age, sex, dietary vitamin D, hours spent sitting at work, and time interval between last meal and blood draw.
Variance explained is the model R2 * 100. The partial R2 for each of the covariates in the individual multivariate models were: age (<0.001), sex (0.070–0.076), dietary vitamin D (0.005–0.008), hours spent sitting at work (0.020–0.026), and time interval between last meal and blood draw (< 0.001)
The variance explained by genotype is the partial R2 * 100 for the individual genotype in a linear regression model with variables for age, sex, dietary vitamin D, hours spent sitting at work, and time interval between last meal and blood draw.