Table 1.
Age-sensitive T cell subsets in spleens of aged (DW/J × C3H/HeJ)F1 dwarf and control mice
T cell subset | Units | Controls 3–7 months | Controls 27–29 months | Dwarf 27–29 months | Old control vs. old dwarf |
---|---|---|---|---|---|
CD4M | % of CD4 | 41 ± 3* | 67 ± 9 | 32 ± 6 | 0.002† |
CD8M | % of CD8 | 19 ± 2 | 70 ± 5 | 14 ± 2 | 0.0001 |
CD4P | % of CD4 | 37 ± 4 | 74 ± 2 | 43 ± 2 | 0.0001 |
CD8P | % of CD8 | 67 ± 2 | 91 ± 1 | 64 ± 2 | 0.0001 |
Percentage of cells with the indicated phenotype, ± standard error of the mean, for n = 6 mice per group.
Significance level for difference between the old control and old dwarf group, calculated by using the Bonferroni/Dunn method after one-way ANOVA.