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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Immunol. 2012 Jul 2;189(3):1274–1284. doi: 10.4049/jimmunol.1103102

Figure 5. LPS induced IL-12 expression requires JNK activity.

Figure 5

BMDC from wild-type (WT) or IL-10−/− mice were pre-treated with (A) SB203580, (B) SP600125, (C) U0126, or a corresponding quantity of vehicle control (DMSO) for 1 hour, and then stimulated with Jagged1-Fc or IgG1 in the presence or absence of 100 ng/ml LPS. Concentration of IL-12 in the supernatant after 8 (C) or 24 h (A and B) was measured by ELISA. Data are mean ± SD of triplicates and are representative of at least 3 independent experiments. Two-way ANOVA with Bonferroni post-test was used to statistically compare stimuli; P<0.05 was considered significant. *** = P<0.001, ns = not significant. ND = not detected.