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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Immunol. 2012 Jul 2;189(3):1274–1284. doi: 10.4049/jimmunol.1103102

Figure 7. Proposed mechanism for Notch and TLR interaction in DC.

Figure 7

Our data support a model whereby non-canonical Notch signaling and both MyD88 dependent and TRIF dependent TLR signalling interact through convergence on PI3K and Akt, which then alters the cytokine profile of these cells by modulating the activities of GSK3β, NKκB, ERK and JNK to enhance transcription of the IL-10 and IL-2 genes, as well as inhibiting generation of biologically active IL-12p70.