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. Author manuscript; available in PMC: 2012 Sep 14.
Published in final edited form as: Curr Cancer Ther Rev. 2011 Nov;7(4):248–260. doi: 10.2174/157339411797642605

Fig. (2). Representation of MAPK and NF-kB pathways involved in DC maturation.

Fig. (2)

MAPK and NF-kB pathways are involved in DC maturation and can be triggered by engagement of TLRs or other stimuli (not shown). This results in a cascade of enzymatic reactions involving various adaptor and intermediate proteins and finishes with downstream activation of molecules that regulate transcription. MAPK p38 aids the binding of NF-kB to its consensus sequence. Both MAPK JNK and NF-kB control the expression of factors involved in antigen presentation, costimulatory and adhesion molecules, and pro-inflammatory cytokines.