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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Neuropharmacology. 2012 Aug 7;63(7):1201–1207. doi: 10.1016/j.neuropharm.2012.07.044

Fig. 4. Effects of repeated SB-334867 (20 mg/kg) treatment on cocaine seeking during extinction and reinstatement.

Fig. 4

Rats received daily vehicle or SB-334867 (20 mg/kg) 30 min prior to or 4 hr after the 1st–7th extinction sessions. Rats received acute vehicle or SB-334867 (20 mg/kg) 30 min prior to the reinstatement tests. Average active lever responding is shown for: A) the average of the last 3 sessions of self-administration (SA) and over the 7 sessions of extinction, B) the last session of extinction and cue-induced reinstatement, and C) the last session of extinction and cocaine primed-reinstatement. *indicates significant differences between groups (p < 0.05). (n = 14–15/group in panel A; n = 7–8/group in panels B and C).