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. 2012 Jul 10;3(6):640–650. doi: 10.18632/oncotarget.543

Figure 2. NDC overcomes DOX resistance in vivo.

Figure 2

(a) Representative tumor sections from RPMI8226/Dox xenografts were examined by fluorescence microscopy for nuclear accumulation of DOX by doxorubicin fluorescence. (b) NDC significantly inhibits the growth of subcutaneous DOX-resistant cancer xenografts PC-3A and RPMI8226/Dox. Representative excised xenograft tumors from each of the four arms are illustrated. NDC significantly blocked tumor growth compared to either ND or NC (N=5, *p<0.005). Post treatment levels of MDR1 expression were measured by (c) immunofluorescence and (d) western blot in RPMI8226/Dox xenografts. (e) BDF1 mice bearing P388/ADR DOX-resistant ascites were treated with vehicle, ND, or NDC. A greater than 50% increase in survival was observed in NDC treated mice compared to ND or vehicle treated mice (N=8, *p<0.005).