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Model showing Rnd3 regulation by the level of effectors and ROCK activity. Rnd3 is targeted for degradation by binding of unknown protein (X) which is sensitive to both the Rnd3(K45R) mutation and the membrane localization of Rnd3. This turnover of Rnd3 is sensitive to Y-27632, indicating that ROCK stimulates such turnover. Effector interaction can prevent the turnover of Rnd3 probably by competing for binding of protein X.
