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. 2012 Sep 15;23(18):3663–3672. doi: 10.1091/mbc.E12-06-0438

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© 2012 Whalen et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — S. purpuratus (Sp) ABCB1a is a homologue of human P-gp and is present in its mature form in the unfertilized egg prior to activation at fertilization. (A) Phylogenetic relationships of Sp ABCB family transporters with human (Hs), Ciona intestinalis (Ci), Strongylocentrotus franciscanus (Sf), Allocentrotus fragilis (Af), Patiria miniata (Pm), Drosophila melanogaster (Dm), Nematostella vectensis (Nv), Daphnia pulex (Dp), Amphimedon queenslandica (Aq), and Saccharomyces cerevisiae (Sc). (B) Immunoblot of ABCB1a in sea urchin egg and embryo cell lysates probed with Ab1-C1 shows that ABCB1a does not increase in abundance or change in glycoform profile at fertilization.