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. 2012 Sep 15;23(18):3663–3672. doi: 10.1091/mbc.E12-06-0438

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© 2012 Whalen et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Three-dimensional analysis of ABCB1a dispersal relative to F-actin filaments indicates efflux activation is mediated by short-range, actin-dependent translocation. F-actin–associated ABCB1a advances tip-ward after fertilization (A–D). Bars indicate percent of ABCB1a spots within 200 nm of actin surface, and zero (y-axis) indicates the tip of the microvillus (n = 6 eggs or embryos × 10 filaments per time). Red line indicates the average microvillar length at each time. Insets, representative actin filament isosurfaces and associated ABCB1a spots (red). Scale bar: 1 μm.