TABLE 2A:
Consensus patterns, secondary structure element, relative surface accessibility, and direct CRM1-binding results for experimental NESs with available 3D structures. Continued
| Protein name | NESdb ID | UniProt ID | NES sequencea | Consensus fitb | PDB ID | SSEc | RSA-NESd | RSA-Φse | Bind CRM1f |
|---|---|---|---|---|---|---|---|---|---|
| Snurportin | 1 | O95149 | 1MEELSQALASSFSV14 | + | 3GB8 | HHHHHHHHHHCCCC | 0.57 | 0.74 | + |
| HIV-REV | 2 | P69718 | 72PLQLPPLERLTL83 | + | 3NBZ | CCCCCCHHHCCC | 0.77 | 0.81 | NT |
| PKIα | 5 | P61925 | 36NELALKLAGLDI47 | + | 3NBY | HHHHHHHCCCCC | 0.58 | 0.71 | + |
| p53 | 6 | P04637 | 336ERFEMFRELNEALEL350 | + | 1OLG | HHHHHHHHHHHHHHH | 0.31 | 0.12 | NT |
| RanBP1 | 7 | P43487 | 175DHAEKVAEKLEALSV189 | + | 1K5D | --------------- | 1.00 | 1.00 | + |
| BRCA1 | 10 | P38398 | 81QLVEELLKIICAFQL95 | + | 1JM7 | HHHHHHHHHHHHHHH | 0.41 | 0.34 | NT |
| MAPKK1/MEK1 | 11 | Q05116 | 28TNLEALQKKLEELEL42 | + | 2Y4I | ---------CCCCCC | 0.88 | 0.76 | + |
| MK2 | 20 | P49138 | 337DVKEEMTSALATMRV351 | + | 1KWP | HHHHHHHHHHHHHCC | 0.29 | 0.12 | + |
| Stat1 | 27 | P42224 | 395STNGSLAAEFRHLQL409 | + | 1BF5 | CCCCCEEEEEEEEE | 0.24 | 0.01 | + |
| mPER2 | 31 | O54943 | 455PSVQELTEQIHRLLM469 | + | 3GDI | HHHHHHHHHHHHHCC | 0.40 | 0.20 | + |
| PLC-δ1 | 33 | P10688 | 160MNFKELKDFLKELNI174 | + | 1DJX | EEHHHHHHHHHCCCC | 0.39 | 0.20 | + |
| p73 | 39 | O15350 | 363ENFEILMKLKESLEL377 | + | 2WTT | HHHHHCCHHHHHHHC | 0.09 | 0.09 | + |
| Smad1 | 40 | Q15797 | 400FETVYELTKMCTIRM414 | + | 1KHU | HHHHHHHHHHHEEEE | 0.29 | 0.05 | NT |
| λPKC | 42 | Q62074 | 241SGKASSSLGLQDFDL255 | + | 1ZRZ | -------CCCCCEEE | 0.63 | 0.25 | NT |
| Yap1p | 45 | P19880 | 609PKYSDIDVDGLCSEL623 | - | 1SSE | CCCCCCCHHHHHHHH | 0.46 | 0.23 | + |
| Cyclin D1 | 54 | P24385 | 281VDLACTPTDVRDVDI295 | + | 3G33 | --------------- | 1.00 | 1.00 | NT |
| p38 | 56 | P0C796 | 119YGEKTTQRDLTELEI133 | + | 1N93 | CCCCCCCCCCCHHHH | 0.50 | 0.38 | NT |
| E2F4 | 65 | Q16254 | 56RRIYDITNVLEGIGL70 | + | 1CF7 | HHHHHHHHHHHHHCC | 0.37 | 0.41 | + |
| RSV M | 79 | P03419 | 192AKIIPYSGLLLVITV206 | – | 2VQP | CEEECCCCCEEEEEC | 0.11 | 0.03 | NT |
| FAK1 | 83 | Q05397 | 90LRSEEVHWLHVDMGV104 | + | 2AEH | CCCCCEEEECCCCEH | 0.32 | 0.18 | NT |
| Q00944 | 90LQSEEVHWLHLDMGV104 | ||||||||
| FAK1 | 83 | Q05397 | 511LQVRKYSLDLASLIL525 | + | 1MP8 | HHHCCCCCCHHHHHH | 0.34 | 0.14 | NT |
| Vpr | 86 | P05928 | 55AGVEAIIRILQQLLF69 | + | 1ESX | CHHHHHHHHHHHHHH | 0.43 | 0.54 | NT |
| Q73369 | 55TGVEALIRILQQLLF69 | ||||||||
| nsP2 | 92 | P36328 | 514IVLNQLCVRFFGLDL528 | + | 2HWK | HHHHHHHHHHHCCCH | 0.03 | 0.04 | NT |
| NPM | 93 | P06748 | 88SLGGFEITPPVVLRL102 | + | 2P1B | EEEEEEECCCEEEEE | 0.19 | 0.16 | NT |
| NPM mutA | 94 | P06748 | 282EAIQDLCLAVEEVSL296 | + | 2VXD | --------------- | 1.00 | 1.00 | + |
| CHP1 | 96 | Q99653 | 133DELLQVLRMMVGVNI147 | + | 2CT9 | HHHHHHHHHHCCCCC | 0.38 | 0.49 | + |
| E1A | 99 | P03255 | 69SVMLAVQEGIDLLTF83 | + | 2KJE | CCCHHHCCCCCHHHC | 0.44 | 0.49 | + |
| ADAR1 | 110 | P55265 | 126LSSHFQELSI135 | + | 1QGP | CHHHHCCCHH | 0.66 | 0.71 | + |
| E7 | 114 | P03129 | 70QSTHVDIRTLEDLLM84 | + | 2EWL | ECCHHHHHHHHHHHH | 0.48 | 0.45 | + |
| P21736 | 78ESSAEDLRTLQQLFL91 | ||||||||
| N protein | 118 | Q88935 | 103EFSLPTHHTVRLIRV117 | + | 1P65 | CCCCCHHHHHHHHHH | 0.52 | 0.60 | NT |
| Hxk2 | 120 | P04807 | 304MSSGYYLGEILRLAL318 | + | 1IG8 | HHCHHHHHHHHHHHH | 0.06 | 0.05 | NT |
| Topo IIα | 121 | P11388 | 1013DTVLDILRDFFELRL1027 | + | 1BGW | CCHHHHHHHHHHHHH | 0.21 | 0.09 | + |
| P06786 | 988NSVNEILSEFYYVRL1002 | ||||||||
| Survivin | 123 | O15392 | 84CAFLSVKKQFEELTL98 | + | 2QFA | CHHHHCCCCHHHCCH | 0.43 | 0.33 | NT |
| NC2β | 126 | Q01658 | 66ISPEHVIQALESLGF80 | + | 1JFI | CCHHHHHHHHHHHCC | 0.34 | 0.23 | + |
| Tbx5 | 127 | Q9PWE8 | 146AHWMRQLVSFQKLKL160 | + | 2X6U | HHHHHCCEECCCCEE | 0.28 | 0.10 | NT |
| Paxillin | 136 | P49023 | 262ATRELDELMASLSDF276 | + | 2VZI | CHHHHHHHHHHC--- | 0.76 | 0.70 | + |
| BPV E1 | 139 | P03116 | 404YQNIELITFINALKL418 | + | 2V9P | HCCCCHHHHHHHHHH | 0.29 | 0.18 | NT |
| CaMKIα | 143 | Q63450 | 307FNATAVVRHMRKLQL321 | + | 1A06 | ECHHHHHHHC----- | 0.58 | 0.79 | + |
| STRADα | 154 | Q7RTN6 | 412SGIFGLVTNLEELEV426 | + | 3GNI | -------------CC | 1.04 | 0.83 | + |
| LEI | 155 | P30740 | 279EESYTLNSDLARLGV293 | + | 1HLE | EEEEECHHHHHHHCC | 0.28 | 0.06 | + |
| P05619 | 279EESYDLTSHLARLGV293 | ||||||||
| MK5 | 165 | O54992 | 328GIQQAHAEQLANMRI342 | + | 2OZA | HHHHHHHHHHHHHCC | 0.33 | 0.20 | NT |
| P49137 | 351DVKEEMTSALATMRV365 | ||||||||
| Dab1 | 168 | P97318 | 146AAEPVILDLRDLFQL160 | + | 1OQN | CCHHHHHHHHHHHHH | 0.26 | 0.08 | NT |
| p28GANK | 173 | O75832 | 1MEGCVSNLMV10 | + | 1QYM | --CCCCCHH | 0.61 | 0.41 | NT |
| 2EGCVSNLMV10 | |||||||||
| SIRT2 | 199 | Q8IXJ6 | 37DMDFLRNLFSQTLSL51 | + | 1J8F | HHHHHHHHC------ | 0.61 | 0.58 | + |
| Hst2 | 212 | P53686 | 303EQLLEIVHDLENLSL317 | + | 1Q14 | CHHHHHHHHHHC--- | 0.46 | 0.60 | NT |
| PP2ACα | 213 | P67775 | 144NVMKYFTDLFDYLPL155 | + | 2IAE | CHHHHHHHHHHHCCC | 0.10 | 0.00 | NT |
| ORF-9b | 214 | P59636 | 41KVYPIILRLGSNLSL55 | + | 2CME | EEEEEEECCCCCCEE | 0.28 | 0.19 | NT |