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. 2012 Jul 20;287(38):31766–31782. doi: 10.1074/jbc.M112.387316

FIGURE 10.

FIGURE 10.

Euglycemic agents can reverse hypothalamic HD MSigDB PAGE collection pathology to different degrees. Isolation of significantly regulated PAGE collections common between the HD mouse hypothalamic pathology set (black circles, HD pathology) and the HD-specific Ex4- (green circle), GLP-1-Tf- (blue circle), or insulin (red circle)-regulated MSigDB PAGE annotated datasets is shown (A). Venn diagram isolation of Ex-4/GLP-1-Tf/insulin-unique HD pathology-related PAGE collections is shown. Ex-4-unique HD pathology-related PAGE collection set is designated α; GLP-1-Tf-unique HD pathology-related PAGE collection set is designated β, and insulin-unique HD pathology-related PAGE collection set is designated γ (B). C, z score distributions of α, β, and γ PAGE collection set constituents. HD pathology-regulated MSigDB PAGE collections are denoted in black, and the drug-dependent PAGE collection regulatory behavior is color-coded as follows: green bars, Ex-4; blue bars, GLP-1-Tf; red bars, insulin. The numerical percentage of these PAGE collections in the sets α, β, or γ that display a reversed polarity of z score regulation between the HD pathology data and the drug-controlled data is indicated in each panel.