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. 2012 Jul 20;287(38):31766–31782. doi: 10.1074/jbc.M112.387316

FIGURE 2.

FIGURE 2.

Genomic correlations in the hypothalamic N171–82Q HD mouse transcriptomic signature. A, genomic heat map representation of the significantly regulated transcripts that possess an implicit semantic correlation (LSI score >0.1) with at least two of the user-defined input interrogator terms (glucose, insulin, diabetes, metabolism, oxidative phosphorylation, neurodegeneration, and Huntington disease). Red blocks indicate the correlation of a correlated gene up-regulated in HD compared with WT controls, and green blocks indicate the correlation of a down-regulated HD-associated gene. Black blocks indicate no significant gene-LSI interrogator term correlation. B, upper panel indicates the mean (red bar) ± S.E. LSI correlation score from all the specifically correlating HD-associated genes with the input LSI interrogator terms. The lower panel displays the numbers and direction of transcript regulation of HD-associated genes correlating with the specific LSI interrogator terms.