FIGURE 2.

Arsenic-induced transformed cells develop tumor in xenograft mouse model. Cells transformed by arsenic exposure had tumorigenic activity in SKH-1 hairless mice (A, left panels). Average tumor volumes (A, right panel), weight (B) and body weight (C) are shown. Data are represented as means ± S.D. Statistical differences were evaluated using the Student's t test and the asterisks (** and ***) indicates a significant difference (p < 0.0005 and p < 0.0001, respectively) between the groups injected with arsenic-transformed cells compared with non-transformed cells.