FIGURE 5.

PPG induced elevated cystathionine significantly protects WT mice against tunicamycin induced steatosis and liver injury. A, representative examples of whole livers dissected out of C57BL/6 WT mice from the four experimental groups. Livers from the Tuc group were all severely enlarged, yellowish, and fatty in appearance. Liver morphology appeared ostensibly normal in mice pretreated with PPG prior to tunicamycin administration. B, liver weight as an index of hepatic enlargement. C, hepatic trigycerides as an index of steatosis and D, plasma ALT as an index of liver injury were determined as described in “Materials and Methods.” Values are means ± S.D. (n = 6).