FIGURE 3.

TCDD induces ABCB6 expression in both mice and humans. Exposure to TCDD induces Abcb6 expression in mouse (A) and human hepatomas (C and D). B, TCDD-mediated induction of Cyp1a1, a gene known to be induced by TCDD in the liver, is used as a positive control in these experiments. Values represent mean ± S.D. (error bars); n = 6 for mice, and n = 4 for cell culture. Results shown are representative of three independent experiments. *, significantly different for vehicle-treated mice in animals and human hepatomas (p < 0.01).