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. 2012 Jul 2;287(38):32054–32068. doi: 10.1074/jbc.M112.371476

FIGURE 5.

FIGURE 5.

A functional AhR pathway is required for B[a]P-mediated up-regulation of ABCB6. Mouse (A) and HepG2 (C) cells lacking AhR are unable to up-regulate Abcb6 expression, whereas mouse (A) and HepG2 (C) cells with functional AhR up-regulate Abcb6 expression in response to B[a]P. B, B[a]P-mediated induction of Cyp1a1, a gene known to be induced by B[a]P, is used as a positive control in these experiments. Values represent mean ± S.D. (error bars); n = 4 for mice, and n = 3 for HepG2. Results representative of three independent experiments. *, significantly different from scrambled siRNA transfected cells; p < 0.01 in hepatomas and AhR+/+ vehicle-treated mice. #, significantly different from AhR siRNA-transfected cells treated with B[a]P. p < 0.01.