FIGURE 1.

Molecular analysis of WBSCR17. A, a phylogenetic tree of the human GalNAc-T family. The tree was generated by comparing amino acid sequences of the family with the ClustalW algorithm. Recently, two distinct numbers were assigned to some of the isozymes by Peng et al. (8) and Raman et al. (7), and both numbers separated by a slash are shown in the tree. WBSCR17 is one of the isozymes that belong to the Y subfamily. B, schematic representation of GalNAc-T motifs and comparison of amino acid sequences in the Gal/GalNAc-T motif. The Y subfamily has a tyrosine residue in place of a tryptophan residue in the Gal/GalNAc-T motif of other GalNAc-T family members (indicated by a gray box).