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. Author manuscript; available in PMC: 2012 Sep 14.
Published in final edited form as: Gastroenterology. 2011 Oct 15;141(6):1986–1999. doi: 10.1053/j.gastro.2011.10.002

Figure 4. Model of Nlrp6-mediated regulation of intestinal and microbial homeostasis.

Figure 4

Nlrp6 maintains intestinal homeostasis by regulating the composition of the gut microbiome and the production of IL-18 (left). In the absence of Nlrp6 (right), there is dysbiosis resulting in the accumulation of colitogenic bacteria, upregulation of inflammatory mediators, such as CCL5, and subclinical inflammation. Upon additional epithelial damage by DSS, rampant inflammation ensues as a result of impaired epithelial repair from decreased IL-18 production..