Figure 1.

Steady-state, peak-to-trough fluctuation in plasma concentration over the recommended dosing interval.

Peak-to-trough fluctuations were calculated as the ratio of mean C_max to mean C_min at the steady-state following administration according to the recommended dosing interval. Source data.^14,19–25

*Dose and injection site affect the pharmacokinetics (including peak-to-trough fluctuation) of paliperidone palmitate. Here the steady-state fluctuation of paliperidone palmitate 117mg was administered in the deltoid muscle. Administration of higher doses and/or gluteal administration may result in less steady-state, peak-to-trough fluctuation. Source data.^27,40,41