TABLE 3.
Selected pharmacokinetic parameters
| DRUG | Tmax | T1/2 |
|---|---|---|
| LAI medications, days | ||
| Haloperidol decanoate18 | 6 | 21 |
| Olanzapine pamoate16,26 | 4 | 30 |
| Paliperidone palmitate27 | 13 | 37* |
| Risperidone LAI†,17 | 35* | 4.5* |
| Zuclopenthixol decanoate14 | 3 | 7.4 |
| Oral medications, hours | ||
| Haloperidol19,28 | 4.9 | 25.6* |
| Olanzapine29 | 6 | 30 |
| Paliperidone ER31 | 24 | 23 |
| Risperidone†,30 | 1.3 | 19.5 |
LAI: long-acting injectable; ER: extended-release; T1/2: terminal half-life; Tmax: time to maximum plasma concentration
*
Where a range was reported, the midpoint of the range is presented here.
†
Risperidone: data reported for the active moiety (risperidone + 9-OH-risperidone).