Figure 4. Host-Specific Gut Microbiota Induction of T Cell Proliferation in Secondary Gut Lymphoid Organs Leads to Expansion of Small Intestinal T Cells.

(A) Representative flow cytometry plots of CD44^hiCD62L^lo (effector/memory) and CD44^loCD62L^hi (naive) expression on CD3⁺CD4⁺ T cells in PPs of MMb and HMb offspring are presented. Numbers indicate cell percentages in the quadrant. (B) Combined data for PP CD3⁺CD4⁺ and CD3⁺CD8⁺ cells (n = 7) are illustrated. (C) Mice injected with BrdU were sacrificed 2 hr later. CD3⁺ T cells were stained with FITC-conjugated antibody to BrdU for detection of proliferating cells. See also Figures S4A–S4C. *p < 0.05, **p < 0.01, ***p < 0.001. NS, not significant.