Figure 2. The MRI signal enhancement of pancreas is enhanced by manganese. T1-weighted magnetic resonance imaging showing the pancreas (area limited by the dashed line) before (A, C) and 20 min after Mn-DPDP infusion (B, D) of a normoglycemic (A, B) and a type 2 diabetic patient (C, D). In both patients, the MRI signal of pancreas was enhanced by the manganese infusion. E) This enhancement was significantly higher in normoglycemic than in type 2 diabetic patients. Data are mean + SEM signal enhancement, expressed as % of the signal evaluated prior to the manganese infusion.