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Analysis of islet integrity and function in 6-week-old CD1d-deficient NOD mice by immunohistochemical staining, using antibodies to CD4 (Left) and α-insulin (Right). Note the periinsulitis in the CD1+/− mice surrounding the intact insulin-stained islet (Left Lower). In contrast, however, at this stage, insulitis and reduced insulin staining are observed in the CD1−/− mice (Right Lower).
