Table 1. Sequenced mutations arising in the supF SV after replication in human cells.

Mutation class		scrambled shCTRL	[TTAGGG]6 shCTRL	scrambled shWRN	[TTAGGG]6 shWRN
Overall mean mutant frequency		5.2x10−4	5.6x10−4	25x10−4	150x10−4
Point Mutations
	mean mutation frequency	2.7x10−4	3.9x10−4	5.2x10−4	33x10−4
	number	11	16	4	5
	proportion of total	0.52	0.70	0.21	0.21
Deletions and Rearrangementsa
	mean mutation Frequency	2.5x10−4	1.7x10−4	20x10−4	120x10−4
	number of mutations	10	7b	15c	19d
	proportion of total	0.48	0.30	0.79	0.79
Total mutations (mutants)		21 (21)	23 (17)	19 (19)	24 (21)

^a Identical deletions or rearrangements from the same SV transfection experiment in human cells were scored once to avoid the inclusion of potential SV siblings (progeny from a single mutagenic event). ^bIncludes a mutation in which one (AGGGTT) repeat was inserted into the [TTAGGG]₆ sequence. ^cIncludes one unknown rearrangement and 14 defined deletions. ^dIncludes four unknown rearrangements, 14 defined deletions, and a mutation in which one (AGGGTT) repeat was deleted from the [TTAGGG]₆ sequence.