Figure 4. Pronounced inflammatory cell and fibroblast infiltration following A. actinomycetemcomitans stimulation.
Histological examination of rat calvarial tissues was used to evaluate the extent of inflammatory infiltrate and fibroblast infiltrate. Representative H&E samples are presented indicating control (PBS) injected (upper panel), and A. actinomycetemcomitans injected samples (middle and lower panels) showing inflammation and bone resorption respectively. Inflammatory cell infiltrate and fibroblast proliferation was enumerated by a pathological scoring system (B and C).Results are expressed as mean with S.E.(n=6 for controls and n=8 for A. actinomycetemcomitans injected samples; **p<0.001, *p<0.05).