Table 2.
Adverse event frequency and severity (maximum National Cancer Institute Common Toxicity Criteria [NCI CTC] grade per category)
| Adverse event/ organ system |
Patients per NCI CTC grade [n (%)] |
|||
|---|---|---|---|---|
| grade 1 | grade 2 | grade 3 | grade 4 | |
|
Hematological |
|
|
|
|
| White blood cells |
33 (31) |
22 (20) |
9 (8) |
6 (6) |
| Granulocytes |
27 (26) |
16 (15) |
5 (5) |
3 (3) |
| Platelets |
16 (15) |
2 (2) |
3 (3) |
1 (1) |
| Hemoglobin |
43 (40) |
40 (37) |
3 (3) |
3 (3) |
| Fever |
20 (19) |
8 (7) |
|
|
|
Non-hematological |
|
|
|
|
| Hair loss |
23 (21) |
79 (73) |
|
|
| Nausea |
53 (49) |
15 (14) |
|
|
| Vomiting |
32 (30) |
10 (9) |
|
|
| Diarrhea |
21 (19) |
8 (7) |
|
1 (1) |
| Constipation |
18 (17) |
1 (1) |
|
|
| Neurology/Motor |
19 (18) |
6 (6) |
4 (4) |
|
| Neurology/Sensory |
28 (26) |
16 (15) |
5 (5) |
|
| Arthralgia |
27 (25) |
9 (8) |
2 (2) |
|
| Myalgia |
20 (19) |
8 (7) |
3 (3) |
|
| Lung function |
11 (10) |
8 (7) |
2 (2) |
3 (3) |
| Pain | 21 (19) | 28 (26) | 8 (7) | |