Table 1.
235del mutation frequencies of ofGJB2allele in the individual studies
| No | Relevant Studies | TOTAL | HETRO | HOMO | TOTAL% |
|---|---|---|---|---|---|
| 1 |
Ohtsuka A, et al. 2003 [10] |
1227 |
92 |
16 |
5.05% |
| 2 |
Batissoco AC, et al. 2009 [11] |
300 |
1 |
0 |
0.17% |
| 3 |
Wattanasirichaigoon D, et al. 2004 [12] |
166 |
6 |
2 |
3.01% |
| 4 |
Padma G, et al. 2009 [13] |
456 |
0 |
1 |
0.22% |
| 5 |
Park HJ, et al. 2000 [14] |
147 |
5 |
5 |
5.10% |
| 6 |
Shalin H, et al. 2002 [15] |
48 |
0 |
1 |
2.08% |
| 7 |
Lee KY, et al. 2008 [16] |
29 |
0 |
2 |
6.90% |
| 8 |
Schimmenti LA, et al. 2008 [17] |
95 |
0 |
1 |
1.05% |
| 9 |
Posukh O, et al. 2005 [18] |
76 |
4 |
1 |
3.95% |
| 10 |
Abe S, et al. 2000 [19] |
35 |
4 |
1 |
8.57% |
| 11 |
Tang, HY et al. 2006 [20] |
610 |
1 |
0 |
0.08% |
| 12 |
Tekin M, et al. 2010 [21] |
534 |
12 |
2 |
1.50% |
| 13 |
Kudo T, et al. 2000 [22] |
63 |
1 |
3 |
5.56% |
| 15 |
Cheng X, et al. 2005 [23] |
740 |
1 |
1 |
0.20% |
| 16 |
Wang YC, et al. 2002 [24] |
169 |
6 |
8 |
6.51% |
| 17 |
Chen D, et al. 2009 [25] |
100 |
10 |
16 |
21.00% |
| 18 |
Xiao ZA, et al. 2004 [26] |
131 |
2 |
9 |
7.63% |
| 19 |
Wang SH, et al. 2009 [27] |
140 |
7 |
20 |
16.79% |
| 20 |
Hwa, HL et al. 2003 [28] |
324 |
16 |
11 |
5.86% |
| 21 |
Shi GZ, et al. 2004 [29] |
20 |
3 |
3 |
22.50% |
| 22 |
Dai P, et al. 2007 [30] |
3004 |
255 |
233 |
12.00% |
| 23 |
Liu ZX, et al. 2002 [31] |
118 |
20 |
14 |
20.34% |
| 24 | Liu YH, et al.2002 [32] | 210 | 13 | 27 | 15.95% |
(*χ2 = 6.667, P <0.05. A significant heterogeneity was found in the 235del mutation frequency of GJB2 allele).