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. 2012 Jun 6;12:212. doi: 10.1186/1471-2407-12-212

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Copyright ©2012 Saini et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Copy number status ofKITand its correlation with expression. (A) dual-colour FISH showing KIT signal (red) and centromeric sequences on chromosome 4 (green) on tissue sections (100x). M37 and non-neoplastic cerebellum (control) show normal, M29 shows decreased KIT copy number. (B) qPCR based KIT copy number results of meningioma cases; whose FISH micrographs have been shown in (A). (C) scatter plot showing relative expression of KIT Vs its copy number in immunopositive meningioma cases.