Table 1. Distribution of modulated genes.
Developmental changes PN56 vs. PN11 | PN11: Effects in Klf5CN vs. WT corneas | ||||
Increased | Decreased | Unchanged | |||
PN56: Effects in Klf5CN vs. WT corneas | Increased | Increased | 37 (22) | 0 (0) | 16 (6) |
Decreased | 99 (42) | 1 (0) | 175 (48) | ||
Unchanged | 230 (79) | 1 (0) | 194 (44) | ||
Decreased | Increased | 0 (0) | 25 (17) | 47 (22) | |
Decreased | 0 (0) | 3 (1) | 17 (5) | ||
Unchanged | 1 (0) | 44 (29) | 73 (26) | ||
Unchanged | Increased | 58 (18) | 31 (11) | 1360 (128) | |
Decreased | 62 (7) | 55 (7) | 1503 (80) | ||
Unchanged | 227 (16) | 139 (48) | 17,417 (304) |
Numbers of unique characterized genes which are differentially expressed in Klf5CN vs. WT corneas at PN11 or at PN56 (rows) are shown. Rows are broken down according to developmental changes, i.e., differences between PN56 WT and PN11 WT corneas, as designated in the shaded column. Data sets discordant between PN11 and PN56 (i.e., increased in PN11 Klf5CN but decreased in PN56 Klf5CN, or vice versa) are too small to be meaningful. Number of genes which also show valid >2-fold changes in PN56 Klf4CN cornea are shown in parentheses.