Table 2. Top 50 genes whose expression is most decreased in PN11 Klf5CN compared with the WT corneas.
| Gene symbol | Description | Mean log intensity in WT | Mean log intensity in Klf5CN | Fold Difference |
| Klf5 | Krüppel-like factor 5 | 9.10 | 3.87 | 0.03 |
| Aqp3 | aquaporin 3 | 11.11 | 7.54 | 0.08 |
| Folr1 | folate receptor 1 (adult) | 8.52 | 5.01 | 0.09 |
| Krt4 | keratin 4 | 7.33 | 4.12 | 0.11 |
| Serpinb3a | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A | 7.10 | 3.90 | 0.11 |
| Ces3 | carboxylesterase 3 | 8.71 | 5.60 | 0.12 |
| Gkn1 | gastrokine 1 | 6.21 | 3.35 | 0.14 |
| Snx31 | sorting nexin 31 | 8.59 | 5.84 | 0.15 |
| Adh6b | alcohol dehydrogenase 6B (class V) | 9.35 | 6.60 | 0.15 |
| Ppp1r3c | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 7.14 | 4.50 | 0.16 |
| Txnip | thioredoxin interacting protein | 9.25 | 6.63 | 0.16 |
| Scd2 | stearoyl-Coenzyme A desaturase 2 | 8.88 | 6.27 | 0.16 |
| Cyp2b19 | cytochrome P450, family 2, subfamily b, polypeptide 19 | 6.29 | 3.68 | 0.16 |
| Cnpy1 | canopy 1 homolog (zebrafish) | 5.95 | 3.40 | 0.17 |
| Pax6 | paired box gene 6 | 9.08 | 6.60 | 0.18 |
| Acaa2 | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 9.39 | 6.94 | 0.18 |
| Syt7 | synaptotagmin VII | 7.12 | 4.73 | 0.19 |
| Sfrp1 | secreted frizzled-related protein 1 | 9.60 | 7.21 | 0.19 |
| Paqr5 | progestin and adipoQ receptor family member V | 8.32 | 5.98 | 0.20 |
| Rapgef3 | Rap guanine nucleotide exchange factor (GEF) 3 | 5.97 | 3.65 | 0.20 |
| Fgf21 | fibroblast growth factor 21 | 6.96 | 4.66 | 0.20 |
| Acsm1 | acyl-CoA synthetase medium-chain family member 1 | 8.38 | 6.10 | 0.21 |
| Jakmip1 | janus kinase and microtubule interacting protein 1 | 7.64 | 5.40 | 0.21 |
| Es22 | esterase 22 | 5.56 | 3.33 | 0.21 |
| Gldc | glycine decarboxylase | 7.03 | 4.83 | 0.22 |
| Ripply3 | ripply3 homolog (zebrafish) | 6.99 | 4.83 | 0.22 |
| Bre | brain and reproductive organ-expressed protein | 9.45 | 7.28 | 0.22 |
| Sox15 | SRY-box containing gene 15 | 8.13 | 5.97 | 0.22 |
| Gpt | glutamic pyruvic transaminase, soluble | 8.29 | 6.18 | 0.23 |
| Tkt | transketolase | 9.66 | 7.55 | 0.23 |
| Stk35 | serine/threonine kinase 35 | 6.18 | 4.07 | 0.23 |
| Ngef | neuronal guanine nucleotide exchange factor | 6.49 | 4.39 | 0.23 |
| Akr1b7 | aldo-keto reductase family 1, member B7 | 9.73 | 7.63 | 0.23 |
| Slc16a12 | solute carrier family 16 (monocarboxylic acid transporters), member 12 | 8.60 | 6.55 | 0.24 |
| Pmm1 | phosphomannomutase 1 | 8.68 | 6.64 | 0.24 |
| Sdc1 | syndecan 1 | 8.01 | 5.99 | 0.25 |
| Mamdc2 | MAM domain containing 2 | 8.05 | 6.03 | 0.25 |
| Ckmt1 | creatine kinase, mitochondrial 1, ubiquitous | 9.50 | 7.49 | 0.25 |
| Tm9sf2 | transmembrane 9 superfamily member 2 | 8.91 | 6.92 | 0.25 |
| Bnc1 | basonuclin 1 | 10.00 | 8.03 | 0.26 |
| Cps1 | carbamoyl-phosphate synthetase 1 | 6.29 | 4.34 | 0.26 |
| Shmt1 | serine hydroxymethyltransferase 1 (soluble) | 5.82 | 3.88 | 0.26 |
| Angptl7 | angiopoietin-like 7 | 11.61 | 9.68 | 0.26 |
| Ascl2 | achaete-scute complex homolog 2 (Drosophila) | 5.35 | 3.44 | 0.27 |
| Padi4 | peptidyl arginine deiminase, type IV | 6.06 | 4.16 | 0.27 |
| Fjx1 | four jointed box 1 (Drosophila) | 8.25 | 6.35 | 0.27 |
| Slc22a18 | solute carrier family 22 (organic cation transporter), member 18 | 6.68 | 4.79 | 0.27 |
| Lemd1 | LEM domain containing 1 | 5.71 | 3.83 | 0.27 |
| Prss32 | protease, serine, 32 | 6.95 | 5.11 | 0.28 |
| Etv4 | ets variant gene 4 (E1A enhancer binding protein, E1AF) | 5.51 | 3.68 | 0.28 |
Genes whose expression is also decreased in the PN56 Klf5CN corneas are shown in bold.