Table 3. Top 50 genes whose expression is most increased in PN11 Klf5CN compared with the WT corneas.
Gene symbol | Description | Mean log intensity in WT | Mean log intensity in Klf5CN | Fold Difference |
Sftpd | surfactant associated protein D | 4.11 | 11.36 | 151.84 |
Ccl8 | chemokine (C-C motif) ligand 8 | 5.31 | 12.04 | 105.55 |
Expi | extracellular proteinase inhibitor | 6.16 | 12.55 | 83.66 |
Lcn2 | lipocalin 2 | 6.72 | 12.06 | 40.53 |
Retnla | resistin like alpha | 5.62 | 10.95 | 40.27 |
Ppbp | pro-platelet basic protein | 3.44 | 8.69 | 37.93 |
Ltf | lactotransferrin | 6.85 | 12.06 | 36.88 |
Cd209e | CD209e antigen | 3.32 | 8.17 | 28.77 |
Cxcl3 | chemokine (C-X-C motif) ligand 3 | 3.32 | 8.13 | 27.94 |
Hp | haptoglobin | 3.63 | 8.36 | 26.49 |
S100a9 | S100 calcium binding protein A9 (calgranulin B) | 5.64 | 10.36 | 26.43 |
Ear11 | eosinophil-associated, ribonuclease A family, member 11 | 3.32 | 8.01 | 25.81 |
Spink12 | serine peptidase inhibitor, Kazal type 11 | 3.45 | 7.99 | 23.23 |
Cxcl17 | chemokine (C-X-C motif) ligand 17 | 5.25 | 9.51 | 19.20 |
Cxcl2 | chemokine (C-X-C motif) ligand 2 | 3.35 | 7.37 | 16.20 |
Cytip | cytohesin 1 interacting protein | 5.55 | 9.54 | 15.84 |
Flt1 | FMS-like tyrosine kinase 1 | 4.11 | 8.09 | 15.80 |
Cxcl5 | chemokine (C-X-C motif) ligand 5 | 6.62 | 10.56 | 15.41 |
Krt16 | keratin 16 | 6.74 | 10.68 | 15.31 |
Sprr1a | small proline-rich protein 1A | 5.86 | 9.68 | 14.12 |
Nrsn1 | neurensin 1 | 3.56 | 7.24 | 12.83 |
Ms4a6d | membrane-spanning 4-domains, subfamily A, member 6D | 5.46 | 9.07 | 12.27 |
Socs3 | suppressor of cytokine signaling 3 | 6.08 | 9.66 | 11.96 |
Slfn4 | schlafen 4 | 3.87 | 7.43 | 11.75 |
Slco1a5 | solute carrier organic anion transporter family, member 1a5 | 3.54 | 7.07 | 11.58 |
S100a8 | S100 calcium binding protein A8 (calgranulin A) | 7.25 | 10.73 | 11.13 |
Ccl9 | chemokine (C-C motif) ligand 9 | 6.52 | 9.99 | 11.11 |
Spink5 | serine peptidase inhibitor, Kazal type 5 | 5.38 | 8.81 | 10.83 |
Cd14 | CD14 antigen | 6.11 | 9.53 | 10.71 |
Cp | ceruloplasmin | 7.60 | 10.98 | 10.40 |
Clec4d | C-type lectin domain family 4, member d | 3.72 | 7.08 | 10.26 |
Stfa2l1 | stefin A2 like 1 | 5.88 | 9.22 | 10.13 |
Ccl6 | chemokine (C-C motif) ligand 6 | 5.42 | 8.76 | 10.06 |
Ifi203 | interferon activated gene 203 | 5.11 | 8.30 | 9.11 |
Chi3l1 | chitinase 3-like 1 | 7.81 | 10.98 | 9.00 |
Ccl5 | chemokine (C-C motif) ligand 5 | 3.32 | 6.47 | 8.89 |
Gcnt2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme | 5.21 | 8.32 | 8.65 |
Sprr2a | small proline-rich protein 2A | 3.32 | 6.43 | 8.62 |
Alox15 | arachidonate 15-lipoxygenase | 6.68 | 9.74 | 8.34 |
Acpp | acid phosphatase, prostate | 4.14 | 7.19 | 8.30 |
Ccl7 | chemokine (C-C motif) ligand 7 | 3.65 | 6.70 | 8.30 |
Tm4sf1 | transmembrane 4 superfamily member 1 | 7.39 | 10.43 | 8.22 |
Cxcl1 | chemokine (C-X-C motif) ligand 1 | 5.99 | 9.01 | 8.08 |
Htra4 | HtrA serine peptidase 4 | 3.32 | 6.33 | 8.02 |
Il1b | interleukin 1 beta | 4.95 | 7.95 | 8.01 |
Nckap1l | NCK associated protein 1 like | 3.44 | 6.42 | 7.90 |
Krt23 | keratin 23 | 5.27 | 8.24 | 7.84 |
Plb1 | phospholipase B1 | 4.05 | 7.01 | 7.77 |
Pmaip1 | phorbol-12-myristate-13-acetate-induced protein 1 | 4.71 | 7.67 | 7.74 |
Slc26a4 | solute carrier family 26, member 4 | 3.39 | 6.33 | 7.71 |
Genes whose expression is also increased in the PN56 Klf5CN corneas are shown in bold.