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. 2012 Sep 14;7(9):e44771. doi: 10.1371/journal.pone.0044771

Table 3. Top 50 genes whose expression is most increased in PN11 Klf5CN compared with the WT corneas.

Gene symbol Description Mean log intensity in WT Mean log intensity in Klf5CN Fold Difference
Sftpd surfactant associated protein D 4.11 11.36 151.84
Ccl8 chemokine (C-C motif) ligand 8 5.31 12.04 105.55
Expi extracellular proteinase inhibitor 6.16 12.55 83.66
Lcn2 lipocalin 2 6.72 12.06 40.53
Retnla resistin like alpha 5.62 10.95 40.27
Ppbp pro-platelet basic protein 3.44 8.69 37.93
Ltf lactotransferrin 6.85 12.06 36.88
Cd209e CD209e antigen 3.32 8.17 28.77
Cxcl3 chemokine (C-X-C motif) ligand 3 3.32 8.13 27.94
Hp haptoglobin 3.63 8.36 26.49
S100a9 S100 calcium binding protein A9 (calgranulin B) 5.64 10.36 26.43
Ear11 eosinophil-associated, ribonuclease A family, member 11 3.32 8.01 25.81
Spink12 serine peptidase inhibitor, Kazal type 11 3.45 7.99 23.23
Cxcl17 chemokine (C-X-C motif) ligand 17 5.25 9.51 19.20
Cxcl2 chemokine (C-X-C motif) ligand 2 3.35 7.37 16.20
Cytip cytohesin 1 interacting protein 5.55 9.54 15.84
Flt1 FMS-like tyrosine kinase 1 4.11 8.09 15.80
Cxcl5 chemokine (C-X-C motif) ligand 5 6.62 10.56 15.41
Krt16 keratin 16 6.74 10.68 15.31
Sprr1a small proline-rich protein 1A 5.86 9.68 14.12
Nrsn1 neurensin 1 3.56 7.24 12.83
Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 5.46 9.07 12.27
Socs3 suppressor of cytokine signaling 3 6.08 9.66 11.96
Slfn4 schlafen 4 3.87 7.43 11.75
Slco1a5 solute carrier organic anion transporter family, member 1a5 3.54 7.07 11.58
S100a8 S100 calcium binding protein A8 (calgranulin A) 7.25 10.73 11.13
Ccl9 chemokine (C-C motif) ligand 9 6.52 9.99 11.11
Spink5 serine peptidase inhibitor, Kazal type 5 5.38 8.81 10.83
Cd14 CD14 antigen 6.11 9.53 10.71
Cp ceruloplasmin 7.60 10.98 10.40
Clec4d C-type lectin domain family 4, member d 3.72 7.08 10.26
Stfa2l1 stefin A2 like 1 5.88 9.22 10.13
Ccl6 chemokine (C-C motif) ligand 6 5.42 8.76 10.06
Ifi203 interferon activated gene 203 5.11 8.30 9.11
Chi3l1 chitinase 3-like 1 7.81 10.98 9.00
Ccl5 chemokine (C-C motif) ligand 5 3.32 6.47 8.89
Gcnt2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme 5.21 8.32 8.65
Sprr2a small proline-rich protein 2A 3.32 6.43 8.62
Alox15 arachidonate 15-lipoxygenase 6.68 9.74 8.34
Acpp acid phosphatase, prostate 4.14 7.19 8.30
Ccl7 chemokine (C-C motif) ligand 7 3.65 6.70 8.30
Tm4sf1 transmembrane 4 superfamily member 1 7.39 10.43 8.22
Cxcl1 chemokine (C-X-C motif) ligand 1 5.99 9.01 8.08
Htra4 HtrA serine peptidase 4 3.32 6.33 8.02
Il1b interleukin 1 beta 4.95 7.95 8.01
Nckap1l NCK associated protein 1 like 3.44 6.42 7.90
Krt23 keratin 23 5.27 8.24 7.84
Plb1 phospholipase B1 4.05 7.01 7.77
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 4.71 7.67 7.74
Slc26a4 solute carrier family 26, member 4 3.39 6.33 7.71

Genes whose expression is also increased in the PN56 Klf5CN corneas are shown in bold.