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. 2012 Sep 14;7(9):e44771. doi: 10.1371/journal.pone.0044771

Table 6. Top 50 genes whose expression is most increased during post-eyelid opening WT corneal maturation between PN11 and PN56.

Gene symbol Description Mean log intensity in PN11 Mean log intensity in PN56 Fold Difference
Dsp desmoplakin 3.56 10.89 160.99
Lce3a late cornified envelope 3A 3.32 10.19 116.53
Scd2 stearoyl-Coenzyme A desaturase 2 4.05 10.28 75.18
Psca prostate stem cell antigen 6.24 11.98 53.45
Clca4 chloride channel calcium activated 4 3.44 8.65 37.16
Dsc3 desmocollin 3 4.79 9.89 34.31
Il1f9 interleukin 1 family, member 9 4.88 9.96 33.83
Lce3c late cornified envelope 3C 3.32 8.12 27.78
Oasl1 oligoadenylate synthetase-like 1 5.47 10.26 27.52
Vps35 vacuolar protein sorting 35 3.95 8.67 26.32
Piga phosphatidylinositol glycan anchor biosynthesis, class A 4.69 9.41 26.29
Prkci protein kinase C, iota 4.15 8.79 25.04
Expi extracellular proteinase inhibitor 6.16 10.76 24.20
Ggta1 glycoprotein galactosyltransferase alpha 1, 3 3.32 7.91 24.00
Il1f6 interleukin 1 family, member 6 3.91 8.45 23.34
Hif1a hypoxia inducible factor 1, alpha subunit 3.80 8.24 21.65
Met met proto-oncogene 3.75 8.15 21.23
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 4.60 9.00 21.15
Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 3.32 7.70 20.75
Pdcd6ip programmed cell death 6 interacting protein 4.61 8.97 20.44
Mxd1 MAX dimerization protein 1 4.03 8.38 20.43
Pdlim5 PDZ and LIM domain 5 4.51 8.80 19.54
Sprr2a small proline-rich protein 2A 3.32 7.55 18.73
Lin7c lin-7 homolog C (C. elegans) 4.44 8.58 17.56
Sftpd surfactant associated protein D 4.11 8.24 17.49
Adam10 a disintegrin and metallopeptidase domain 10 3.58 7.70 17.47
Vcl Vinculin 3.32 7.44 17.42
Trp63 transformation related protein 63 3.71 7.82 17.28
Tgfbr1 transforming growth factor, beta receptor I 3.32 7.38 16.67
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 4.61 8.54 15.26
Spink5 serine peptidase inhibitor, Kazal type 5 5.38 9.30 15.21
Sdcbp2 syndecan binding protein (syntenin) 2 4.54 8.46 15.07
Gja1 gap junction protein, alpha 1 6.03 9.91 14.68
Obfc2a oligonucleotide/oligosaccharide-binding fold containing 2A 4.96 8.82 14.50
Cxadr coxsackie virus and adenovirus receptor 3.75 7.61 14.50
Mff mitochondrial fission factor 7.34 11.19 14.37
Sprr1a small proline-rich protein 1A 5.86 9.69 14.26
Clic5 chloride intracellular channel 5 4.48 8.26 13.78
Nr1d2 nuclear receptor subfamily 1, group D, member 2 3.32 7.10 13.74
Pax6 paired box gene 6 4.54 8.30 13.60
Gch1 GTP cyclohydrolase 1 4.66 8.43 13.56
Il1a interleukin 1 alpha 4.09 7.84 13.45
Dnm1l dynamin 1-like 3.32 7.07 13.39
Ide insulin degrading enzyme 4.54 8.28 13.39
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 7.41 11.14 13.28
Dock1 dedicator of cytokinesis 1 3.39 7.10 13.10
Sgpl1 sphingosine phosphate lyase 1 3.32 7.03 13.06
Malat1 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) 7.96 11.66 13.05
Slc19a2 solute carrier family 19 (thiamine transporter), member 2 4.74 8.44 13.00
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 3.32 7.00 12.79

Genes encoding cell junctional complex components or markers of epithelial stratification are shown in bold.