Table 6. Top 50 genes whose expression is most increased during post-eyelid opening WT corneal maturation between PN11 and PN56.
Gene symbol | Description | Mean log intensity in PN11 | Mean log intensity in PN56 | Fold Difference |
Dsp | desmoplakin | 3.56 | 10.89 | 160.99 |
Lce3a | late cornified envelope 3A | 3.32 | 10.19 | 116.53 |
Scd2 | stearoyl-Coenzyme A desaturase 2 | 4.05 | 10.28 | 75.18 |
Psca | prostate stem cell antigen | 6.24 | 11.98 | 53.45 |
Clca4 | chloride channel calcium activated 4 | 3.44 | 8.65 | 37.16 |
Dsc3 | desmocollin 3 | 4.79 | 9.89 | 34.31 |
Il1f9 | interleukin 1 family, member 9 | 4.88 | 9.96 | 33.83 |
Lce3c | late cornified envelope 3C | 3.32 | 8.12 | 27.78 |
Oasl1 | oligoadenylate synthetase-like 1 | 5.47 | 10.26 | 27.52 |
Vps35 | vacuolar protein sorting 35 | 3.95 | 8.67 | 26.32 |
Piga | phosphatidylinositol glycan anchor biosynthesis, class A | 4.69 | 9.41 | 26.29 |
Prkci | protein kinase C, iota | 4.15 | 8.79 | 25.04 |
Expi | extracellular proteinase inhibitor | 6.16 | 10.76 | 24.20 |
Ggta1 | glycoprotein galactosyltransferase alpha 1, 3 | 3.32 | 7.91 | 24.00 |
Il1f6 | interleukin 1 family, member 6 | 3.91 | 8.45 | 23.34 |
Hif1a | hypoxia inducible factor 1, alpha subunit | 3.80 | 8.24 | 21.65 |
Met | met proto-oncogene | 3.75 | 8.15 | 21.23 |
Mobkl1b | MOB1, Mps One Binder kinase activator-like 1B (yeast) | 4.60 | 9.00 | 21.15 |
Sema4d | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 3.32 | 7.70 | 20.75 |
Pdcd6ip | programmed cell death 6 interacting protein | 4.61 | 8.97 | 20.44 |
Mxd1 | MAX dimerization protein 1 | 4.03 | 8.38 | 20.43 |
Pdlim5 | PDZ and LIM domain 5 | 4.51 | 8.80 | 19.54 |
Sprr2a | small proline-rich protein 2A | 3.32 | 7.55 | 18.73 |
Lin7c | lin-7 homolog C (C. elegans) | 4.44 | 8.58 | 17.56 |
Sftpd | surfactant associated protein D | 4.11 | 8.24 | 17.49 |
Adam10 | a disintegrin and metallopeptidase domain 10 | 3.58 | 7.70 | 17.47 |
Vcl | Vinculin | 3.32 | 7.44 | 17.42 |
Trp63 | transformation related protein 63 | 3.71 | 7.82 | 17.28 |
Tgfbr1 | transforming growth factor, beta receptor I | 3.32 | 7.38 | 16.67 |
Slc1a1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 4.61 | 8.54 | 15.26 |
Spink5 | serine peptidase inhibitor, Kazal type 5 | 5.38 | 9.30 | 15.21 |
Sdcbp2 | syndecan binding protein (syntenin) 2 | 4.54 | 8.46 | 15.07 |
Gja1 | gap junction protein, alpha 1 | 6.03 | 9.91 | 14.68 |
Obfc2a | oligonucleotide/oligosaccharide-binding fold containing 2A | 4.96 | 8.82 | 14.50 |
Cxadr | coxsackie virus and adenovirus receptor | 3.75 | 7.61 | 14.50 |
Mff | mitochondrial fission factor | 7.34 | 11.19 | 14.37 |
Sprr1a | small proline-rich protein 1A | 5.86 | 9.69 | 14.26 |
Clic5 | chloride intracellular channel 5 | 4.48 | 8.26 | 13.78 |
Nr1d2 | nuclear receptor subfamily 1, group D, member 2 | 3.32 | 7.10 | 13.74 |
Pax6 | paired box gene 6 | 4.54 | 8.30 | 13.60 |
Gch1 | GTP cyclohydrolase 1 | 4.66 | 8.43 | 13.56 |
Il1a | interleukin 1 alpha | 4.09 | 7.84 | 13.45 |
Dnm1l | dynamin 1-like | 3.32 | 7.07 | 13.39 |
Ide | insulin degrading enzyme | 4.54 | 8.28 | 13.39 |
Slc5a1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 7.41 | 11.14 | 13.28 |
Dock1 | dedicator of cytokinesis 1 | 3.39 | 7.10 | 13.10 |
Sgpl1 | sphingosine phosphate lyase 1 | 3.32 | 7.03 | 13.06 |
Malat1 | metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) | 7.96 | 11.66 | 13.05 |
Slc19a2 | solute carrier family 19 (thiamine transporter), member 2 | 4.74 | 8.44 | 13.00 |
Atrx | alpha thalassemia/mental retardation syndrome X-linked homolog (human) | 3.32 | 7.00 | 12.79 |
Genes encoding cell junctional complex components or markers of epithelial stratification are shown in bold.