Table 7. Top 50 genes whose expression is most decreased during post-eyelid opening WT corneal maturation between PN11 and PN56.
Gene symbol | Description | Mean log intensity in PN11 | Mean log intensity in PN56 | Fold Difference |
Mfap4 | microfibrillar-associated protein 4 | 11.77 | 3.94 | 0.00 |
Cpz | carboxypeptidase Z | 10.50 | 3.59 | 0.01 |
Col11a1 | collagen, type XI, alpha 1 | 10.77 | 4.05 | 0.01 |
Col9a1 | collagen, type IX, alpha 1 | 11.51 | 4.81 | 0.01 |
Col5a2 | collagen, type V, alpha 2 | 12.06 | 5.95 | 0.01 |
Meg3 | maternally expressed 3 | 11.22 | 5.14 | 0.02 |
Col5a1 | collagen, type V, alpha 1 | 10.43 | 4.50 | 0.02 |
Dlk1 | delta-like 1 homolog (Drosophila) | 10.15 | 4.23 | 0.02 |
Agtr2 | angiotensin II receptor, type 2 | 10.19 | 4.28 | 0.02 |
Fmod | fibromodulin | 11.95 | 6.08 | 0.02 |
Rian | RNA imprinted and accumulated in nucleus | 9.47 | 3.61 | 0.02 |
H19 | H19 fetal liver mRNA | 11.32 | 5.48 | 0.02 |
Adamts2 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 | 9.48 | 3.68 | 0.02 |
Matn4 | matrilin 4 | 11.63 | 5.95 | 0.02 |
Col3a1 | collagen, type III, alpha 1 | 11.26 | 5.81 | 0.02 |
Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 12.06 | 6.73 | 0.03 |
Thbs2 | thrombospondin 2 | 11.78 | 6.49 | 0.03 |
Twist2 | twist homolog 2 (Drosophila) | 9.03 | 3.82 | 0.03 |
Clec3b | C-type lectin domain family 3, member b | 8.77 | 3.57 | 0.03 |
Aplnr | apelin receptor | 9.21 | 4.04 | 0.03 |
Cryga | crystallin, gamma A | 9.02 | 3.89 | 0.03 |
Mfap2 | microfibrillar-associated protein 2 | 11.15 | 6.07 | 0.03 |
Fbn2 | fibrillin 2 | 9.06 | 4.00 | 0.03 |
Ctsk | cathepsin K | 11.39 | 6.39 | 0.03 |
Dpep1 | dipeptidase 1 (renal) | 10.50 | 5.53 | 0.03 |
Col6a2 | collagen, type VI, alpha 2 | 12.35 | 7.49 | 0.03 |
Kazald1 | Kazal-type serine peptidase inhibitor domain 1 | 9.89 | 5.05 | 0.04 |
Aspn | Aspirin | 9.25 | 4.41 | 0.04 |
Mmp23 | matrix metallopeptidase 23 | 8.04 | 3.32 | 0.04 |
Thbs4 | thrombospondin 4 | 11.04 | 6.35 | 0.04 |
Camk4 | calcium/calmodulin-dependent protein kinase IV | 8.28 | 3.60 | 0.04 |
C1qtnf2 | C1q and tumor necrosis factor related protein 2 | 9.40 | 4.80 | 0.04 |
Mcpt4 | mast cell protease 4 | 8.04 | 3.44 | 0.04 |
Itih5 | inter-alpha (globulin) inhibitor H5 | 8.06 | 3.47 | 0.04 |
Pi16 | peptidase inhibitor 16 | 8.09 | 3.51 | 0.04 |
Lox | lysyl oxidase | 11.18 | 6.60 | 0.04 |
Mfap5 | microfibrillar associated protein 5 | 8.13 | 3.60 | 0.04 |
Col6a1 | collagen, type VI, alpha 1 | 12.49 | 7.97 | 0.04 |
Col24a1 | collagen, type XXIV, alpha 1 | 7.84 | 3.32 | 0.04 |
Aebp1 | AE binding protein 1 | 9.73 | 5.22 | 0.04 |
Pycr1 | pyrroline-5-carboxylate reductase 1 | 8.34 | 3.84 | 0.04 |
Mmp2 | matrix metallopeptidase 2 | 11.37 | 6.87 | 0.04 |
Pdgfrl | platelet-derived growth factor receptor-like | 11.01 | 6.54 | 0.05 |
B3gnt9 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 | 8.44 | 3.98 | 0.05 |
Tac1 | tachykinin 1 | 8.86 | 4.41 | 0.05 |
Angptl7 | angiopoietin-like 7 | 11.61 | 7.17 | 0.05 |
Creb3l1 | cAMP responsive element binding protein 3-like 1 | 8.40 | 3.96 | 0.05 |
Cgref1 | cell growth regulator with EF hand domain 1 | 7.74 | 3.32 | 0.05 |
Gpx7 | glutathione peroxidase 7 | 9.69 | 5.27 | 0.05 |
Gpr124 | G protein-coupled receptor 124 | 8.53 | 4.13 | 0.05 |
Igfbp4 | insulin-like growth factor binding protein 4 | 11.62 | 7.24 | 0.05 |
ECM-associated genes are shown in bold.