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. 2012 Sep 14;7(9):e44771. doi: 10.1371/journal.pone.0044771

Table 7. Top 50 genes whose expression is most decreased during post-eyelid opening WT corneal maturation between PN11 and PN56.

Gene symbol Description Mean log intensity in PN11 Mean log intensity in PN56 Fold Difference
Mfap4 microfibrillar-associated protein 4 11.77 3.94 0.00
Cpz carboxypeptidase Z 10.50 3.59 0.01
Col11a1 collagen, type XI, alpha 1 10.77 4.05 0.01
Col9a1 collagen, type IX, alpha 1 11.51 4.81 0.01
Col5a2 collagen, type V, alpha 2 12.06 5.95 0.01
Meg3 maternally expressed 3 11.22 5.14 0.02
Col5a1 collagen, type V, alpha 1 10.43 4.50 0.02
Dlk1 delta-like 1 homolog (Drosophila) 10.15 4.23 0.02
Agtr2 angiotensin II receptor, type 2 10.19 4.28 0.02
Fmod fibromodulin 11.95 6.08 0.02
Rian RNA imprinted and accumulated in nucleus 9.47 3.61 0.02
H19 H19 fetal liver mRNA 11.32 5.48 0.02
Adamts2 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 9.48 3.68 0.02
Matn4 matrilin 4 11.63 5.95 0.02
Col3a1 collagen, type III, alpha 1 11.26 5.81 0.02
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 12.06 6.73 0.03
Thbs2 thrombospondin 2 11.78 6.49 0.03
Twist2 twist homolog 2 (Drosophila) 9.03 3.82 0.03
Clec3b C-type lectin domain family 3, member b 8.77 3.57 0.03
Aplnr apelin receptor 9.21 4.04 0.03
Cryga crystallin, gamma A 9.02 3.89 0.03
Mfap2 microfibrillar-associated protein 2 11.15 6.07 0.03
Fbn2 fibrillin 2 9.06 4.00 0.03
Ctsk cathepsin K 11.39 6.39 0.03
Dpep1 dipeptidase 1 (renal) 10.50 5.53 0.03
Col6a2 collagen, type VI, alpha 2 12.35 7.49 0.03
Kazald1 Kazal-type serine peptidase inhibitor domain 1 9.89 5.05 0.04
Aspn Aspirin 9.25 4.41 0.04
Mmp23 matrix metallopeptidase 23 8.04 3.32 0.04
Thbs4 thrombospondin 4 11.04 6.35 0.04
Camk4 calcium/calmodulin-dependent protein kinase IV 8.28 3.60 0.04
C1qtnf2 C1q and tumor necrosis factor related protein 2 9.40 4.80 0.04
Mcpt4 mast cell protease 4 8.04 3.44 0.04
Itih5 inter-alpha (globulin) inhibitor H5 8.06 3.47 0.04
Pi16 peptidase inhibitor 16 8.09 3.51 0.04
Lox lysyl oxidase 11.18 6.60 0.04
Mfap5 microfibrillar associated protein 5 8.13 3.60 0.04
Col6a1 collagen, type VI, alpha 1 12.49 7.97 0.04
Col24a1 collagen, type XXIV, alpha 1 7.84 3.32 0.04
Aebp1 AE binding protein 1 9.73 5.22 0.04
Pycr1 pyrroline-5-carboxylate reductase 1 8.34 3.84 0.04
Mmp2 matrix metallopeptidase 2 11.37 6.87 0.04
Pdgfrl platelet-derived growth factor receptor-like 11.01 6.54 0.05
B3gnt9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 8.44 3.98 0.05
Tac1 tachykinin 1 8.86 4.41 0.05
Angptl7 angiopoietin-like 7 11.61 7.17 0.05
Creb3l1 cAMP responsive element binding protein 3-like 1 8.40 3.96 0.05
Cgref1 cell growth regulator with EF hand domain 1 7.74 3.32 0.05
Gpx7 glutathione peroxidase 7 9.69 5.27 0.05
Gpr124 G protein-coupled receptor 124 8.53 4.13 0.05
Igfbp4 insulin-like growth factor binding protein 4 11.62 7.24 0.05

ECM-associated genes are shown in bold.