Table 11. Canonical pathways enriched among genes with reduced expression in Klf5CN corneas.
| PN11 Klf5CN | PN56 Klf5CN | Aggregate | ||||
| Canonical Pathway (Total number of genes in pathway) | −log(p) | Number of genes | −log(p) | Number of genes | −log(p) | Number of genes |
| LPS/IL-1 Mediated Inhibition of RXR Function (223) | 4.5 | 11 | 3.62 | 8 | 5.67 | 15 |
| Metabolism of Xenobiotics by Cytochrome P450 (197) | 4.82 | 8 | 2.16 | 4 | 5.38 | 10 |
| Glutathione Metabolism (92) | 4.29 | 6 | 2 | 4.35 | 7 | |
| Xenobiotic Metabolism Signaling (296) | 2.33 | 9 | 4.2 | 10 | 3.68 | 14 |
| Arachidonic Acid Metabolism (208) | 4.02 | 8 | 2 | 2.97 | 8 | |
| Fatty Acid Metabolism (185) | 3.31 | 7 | 3 | 3.75 | 9 | |
| Glycerolipid Metabolism (154) | 2.21 | 5 | 3 | 3.58 | 8 | |
| Mechanisms of Viral Exit from Host Cells (45) | 2.84 | 4 | 1 | 3.18 | 5 | |
| Butanoate Metabolism (129) | 3 | 3 | 3.08 | 6 | ||
| Eicosanoid Signaling (77) | 3.05 | 5 | 1 | 2.36 | 5 | |
| Valine, Leucine and Isoleucine Degradation (108) | 3 | 3 | 2.82 | 6 | ||
| PXR/RXR Activation (89) | 2 | 2.78 | 4 | 2.36 | 5 | |
| Cysteine Metabolism (90) | 2.6 | 4 | 2 | 2.04 | 4 | |
| Retinol Metabolism (61) | 1 | 2.56 | 3 | 2.56 | 4 | |
| Propanoate Metabolism (122) | 2 | 3 | 2.36 | 5 | ||
| NRF2-mediated Oxidative Stress Response (192) | 6 | 5 | 2.27 | 9 | ||
| Chondroitin Sulfate Biosynthesis (68) | 3 | 2.19 | 3 | 2.08 | 4 | |
| Aryl Hydrocarbon Receptor Signaling (159) | 4 | 2.18 | 5 | 7 | ||
| Urea Cycle and Metabolism of Amino Groups (78) | 2.14 | 3 | 3 | |||
| β-alanine Metabolism (93) | 1 | 2.11 | 3 | 4 | ||
Pathways were selected where at least one group was significantly enriched at p<0.01 (i.e., −log(p)>2). For clarity, −log(p) cells are left blank if −log(p)<2.