Fig. 5.

Model for the transinteraction of nectins. (Left) The transinteraction of two nectin molecules from opposing cells through their IgV domains, which represents a physiologically relevant model of the productive transinteraction. (Right) Models in which two nectin molecules first form a cis-dimer on the cell surface via their IgV domains; these cis-dimers subsequently form transinteractions in a head-to-head manner as proposed by Narita et al. (16).