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. 2012 Aug 27;109(37):15048–15053. doi: 10.1073/pnas.1203085109

Fig. 5.

Fig. 5.

Effects of Sclerostin blocking antibodies (Sost-Ab) on bone response to iPTH. (A) Femur BMD gain. (B) BV/TV of the distal femur. (C) CtTV and CtBV of the midshaft femur. (D) Biomechanical properties of the cortical tibia. (E) Moment of inertia. (F) Difference of seric osteocalcin levels between the end and the beginning of the treatments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 PTH vs. vehicle in pretreatment (Sost-Ab or control-Ab) and genotype (Postn+/+ or Postn−/−). Bars shows mean (± SEM). Open bars, Control-Ab+vehicle; closed bars, Control-Ab+PTH (40 μg⋅kg⋅d); light shaded bars, Sost-Ab+vehicle; dark shaded bars, Sost-Ab+PTH (40 μg⋅kg⋅d).