Table 2. Comparison of tissue methylmalonic acid levels of the mouse pups pre- and post-birth.* .
| Mouse genotype | Age | Liver (nmol/g tissue) | Kidney (nmol/g tissue) | Brain (nmol/g tissue) |
| Control pup ( Mut +/+) | 1 day prior to birth | 10±0 (5) | 10±10 (5) | 0±0 (5) |
| 0–16 hours after birth | 10±10 (10) | 20±20 (9) | 10±10 (10) | |
| MMA Knockout pup ( Mut−/− ) | 1 day prior to birth | 156±156 (2) | 200±200 (2) | 255±66 (2) |
| 0–16 hours after birth | 5070±3040 (4) | 2850±1780 (3) | 1190±50 (3) | |
| MMA Knockout stop codon pup ( Mut−/−MUT Stop+/−) | 1 day prior to birth | 430±120 (3) | 370±490 (3) | 130±170 (3) |
| 0–16 hours after birth | 670±80 (2) | 1470±100 (2) | 150±150 (2) | |
| MMA stop codon rescue pup ( Mut−/−MUT Stop+/− MUT2h +/− ) | 1 day prior to birth | 80±10 (2) | 20±20 (2) | 10±10 (2) |
| 0–16 hours after birth | 50±40 (5) | 120±20 (4) | 30±20 (4) |
*
Results presented as mean ± SEM. Number of samples in parenthesis.