Table 1.

Intestinal total [³H]-radioactivity, radioactivity attributed to ribavirin plus its phosphorylated metabolites, or the ratio of these values in wild type and Ent1(−/−) mice after 30 minute intestinal perfusions with ribavirin at the concentrations listed.

	Total Radioactivity (Ribavirin Equivalents, μM)		Ribavirin + Phosphorylated Metabolites, μM		Total Radioactivity
					RBV+Phosphorylated Metabolites
Perfusate Conc. (μM)	Wild Type	Ent1(−/−)	Wild Type	Ent1(−/−)	Wild Type	Ent1(−/−)
20	0.12 ± 0.04	0.81 ± 0.25***	0.02 ± 0.01	0.14 ± 0.10***	6.00 ± 3.83	5.79 ± 1.55
200	22.50 ± 0.34***	24.50 ± 0.34†††	12.50 ± 3.7***	17.20 ± 9.8†††	1.79 ± 0.81*	1.42 ± 0.99†
5000	495.00 ± 0.18***	545.00± 0.47†††	240.00 ± 92.5***	227.50 ± 112.5††	2.06 ± 1.30*	2.40 ± 1.36

Values = mean ± standard deviation from 4 independent experiments. Significant differences are for dose-normalized comparisons.

^***p<0.001,

^**p<0.01,

^*p<0.05 compared to wild type 20 μM

^†††p<0.001,

^††p<0.01,

^†p<0.05 compared to wild type 20 μM