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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Cell Microbiol. 2012 Jun 26;14(10):1544–1553. doi: 10.1111/j.1462-5822.2012.01819.x

Fig 7. Diagrammatic representation of the host cell signaling pathways activated by C. neoformans Plb1 for transcytosis of HBMEC monolayer.

Fig 7

For transcytosis of HBMEC monolayer, C. neoformans Plb1 is likely to interact with the blood-brain barrier and activate host cell Rac1. Activated Rac1 (GTP-Rac1) in turn interacts with STAT3, which we hypothesize aids in actin cytoskeleton rearrangements involved in C. neoformans transcytosis across HBMEC monolayer. We also hypothesize that the cytosolic phospholipase-like domain present in the C-terminal of Plb1 is likely to act on host cell phospholipids to release lipid mediators, which are involved in activating Rac1.