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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Differentiation. 2012 Jun 6;84(3):252–260. doi: 10.1016/j.diff.2012.05.004

Figure 3.

Figure 3

Müllerian duct epithelium (MDE) is the solo source of the adult vaginal epithelium.

The contributions of MDE, Wolffian duct epithelium (WDE) and urogenital sinus epithelium (UGE) were examined by the presence of enhanced green fluorescent protein (EGFP)-positive cells throughout the surface of the entire vagina in 4-week-old females containing the transgene for Rosa-tdTomato-EGFP and one of the following: Pax2-Cre (EGFP is expressed in the MDE and WDE, A), Osr1-Cre (EGFP is expressed in the UGE, B), and Hoxb7-Cre (EGFP is expressed in WDE, C). The cranial portion of the vagina is visible at the top of each panel. EGFP-positive cells were present in the vaginal epithelium of Pax2-Cre, but not Osr1-Cre or Hoxb7-Cre reporter mice. Bars = 50 μm (Kurita, 2010).