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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2012 Jul 15;18(10):1488–1499. doi: 10.1016/j.bbmt.2012.07.009

Figure 1. A novel GVHD model induced by TEa CD4+ TCR transgenic T cells alone.

Figure 1

Graded numbers (1×103 to 1×105) of purified TEa cells were transplanted into lethally irradiated CB6F1 recipients along with 1×107 T-cell-depleted BM cells. Mice were monitored for the development of GVHD. Each groups contained 4–5 mice. Consistent results were obtained using 1×104 and 1×105 TEa cells in more than 3 other independent experiments. (A) Survival. p<0.005 (5×104 or 1×105 versus TCD BM only, 1×103, 5×103, and 1×104). (B) Body weight.. p<0.001, 1×105 versus TCD BM only, 1×103, 5×103, and 1×104 on day 7 and14; p<0.05, 1×105 versus TCD BM only, 1×103, and 5×103 on day 21.