Table 2.

Multivariate analysis of risk factors for all and lower respiratory tract (LRT) HPIV Infections.

	All HPIV		LRTI
Factor	Risk ratio (95% CI)	P-value	Risk ratio (95% CI)	P-value
Donor type
Autologous	Ref		Ref
UCB	1.4 (0.8-2.5)	0.31	2.4 (1.0-6.1)	0.06
Matched related	0.9 (0.6-1.6)	0.80	1.4 (0.6-3.2)	0.41
Matched unrelated	2.0 (1.1-3.7)	0.03	2.3 (0.8-6.0)	0.11
Mismatched related	3.2 (1.6-6.3)	< 0.01	7.0 (2.7-18.3)	< 0.01
Mismatched unrelated	1.3 (0.6-2.7)	0.55	0.9 (0.3-3.8)	0.98
Gender
Male	Ref		Ref
Female	0.9 (0.7-1.3)	0.75	0.6 (0.3-1.0)	0.04
Diagnosis category
Lymphoid/malignant	1.2 (0.8-1.8)	0.46	1.0 (0.5-1.9)	0.89
Myeloid/malignant	Ref		Ref
Non-malignant	1.1 (0.7-1.8)	0.66	0.9 (0.4-2.1)	0.89
CMV
R+	1.0 (0.7-1.5)	0.80	1.5 (0.9-2.5)	0.15
R−/D−	Ref		Ref
R−/D+	0.9 (0.4-1.7)	0.66	1.2 (0.5-3.2)	0.66
Unknown	2.1 (0.6-6.9)	0.22	0.0 (0.0-0.0)	0.98
Age
Age < 10 years	0.8 (0.5-1.3)	0.42	0.6 (0.3-1.3)	0.18
Age 10-19	0.5 (0.3-0.9)	0.03	0.5 (0.2-1.1)	0.07
Age ≥ 20	Ref		Ref
Transplant Era
1974-1992	0.8 (0.5-1.4)	0.56	0.8 (0.4-1.6)	0.47
1993-2001	0.7 (0.3-1.8)	0.48	0.9 (0.5-1.7)	0.71
2002-2010	Ref		Ref
RIC (risk < 30 days)	0.7 (0.3-1.8)	0.48	0.5 (0.1-1.9)	0.54
RIC (risk ≥ 30 days)	2.1 (1.2-3.5)	0.01	1.4 (0.6-3.1)	0.42
Acute GVHD	1.9 (1.1-3.4)	0.03	2.1 (0.8-5.3)	0.11
Chronic GVHD	6.2 (3.7-10.4)	< 0.01	7.1 (3.4-14.8)	< 0.01

Abbreviations: GVHD, graft-versus-host disease; Ref, reference group for each comparison category; RIC; reduced intensity conditioning; UCB, umbilical cord blood