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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: J Pharm Biomed Anal. 2012 May 23;70:320–329. doi: 10.1016/j.jpba.2012.05.008

Table 2.

Matrix effect factor of bupropion and its three metabolites in umbilical cord plasma (n=3)

Bio-matrix Analytea Added concentrationb Matrix factorc (%) Precision (RSD, %)
Umbilical cord plasma BUP 0.625
188		 94.9
100.1		 7.6
1.4
OH-BUP 1.79
536.2		 99.5
100.0		 5.9
1.8
EB 0.612
184		 98.9
99.5		 4.0
1.5
TB 0.912
274		 98.5
100.3		 4.8
2.8
Placental tissue BUP 0.625
188		 100.5
99.2		 2.6
0.9
OH-BUP 1.79
537		 100.2
100.7		 1.5
0.9
EB 0.610
183		 100.0
101.1		 2.8
0.9
TB 1.84
550		 103.7
100.2		 2.8
0.4
a

BUP=buproipion, OH-BUP=hydroxybupropion, EB=erythrohydrobupropion, TB=threohydrobupropion.

b

The unit of analyte in umbilical cord plasma is ng/mL; the unit of analyte in placental tissue is ng/g.

c

Matrix factor=(peak area of post-extract sample/peak area of pure standard)×100