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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: J Pharm Biomed Anal. 2012 May 23;70:320–329. doi: 10.1016/j.jpba.2012.05.008

Table 5.

Extraction recovery of the bupropion and its three metabolites in umbilical cord plasma and placental tissue (n=3).

Bio-matrix Analytea Added concentrationb Mean recoveryc (%) Precision (RSD, %)
Umbilical cord plasma BUP 0.625
62.5
188		 92.4
89.2
91.3		 6.8
4.8
2.9
OH-BUP 1.79
179
536		 95.5
91.9
94.7		 4.8
4.1
4.3
EB 0.612
61.2
184		 95.9
88.6
93.0		 3.0
5.8
1.4
TB 0.912
91.2
274		 94.0
90.0
93.0		 2.5
5.1
1.3
Placental tissue BUP 0.625
62.5
188		 64.3
66.1
67.4		 10.8
18.6
15.2
OH-BUP 1.79
179
537		 73.3
75.9
76.5		 17.4
18.3
14.7
EB 0.610
61.0
183		 69.6
73.0
76.0		 18.3
18.4
15.7
TB 1.84
184
550		 73.4
77.7
79.8		 17.5
16.9
14.7
a

BUP=buproipion, OH-BUP=hydroxybupropion, EB=erythrohydrobupropion, TB=threohydrobupropion.

b

The unit of analyte in umbilical cord plasma is ng/mL; the unit of analyte in placental tissue is ng/g.

c

Recovery= (peak area of QC sample/peak area of post-extract sample)×100