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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Exp Neurol. 2012 Jul 28;237(2):444–452. doi: 10.1016/j.expneurol.2012.07.013

Figure 1.

Figure 1

A) Protein carbonyl content in Psy- and NAC-treated MO3.13 cells. Psy treatment results in an elevation of protein carbonyls compared to either untreated or NAC-treated cells (p < .005). Cells treated with 10mM NAC along with Psy results in protein carbonyl levels that are indistinguishable from untreated cells (p > .09, n=4 per treatment group). B, C) Oxidative stress in the brain of Twi mice. Protein carbonyl content was measured quantitatively (B and D) through a colorimetric assay and qualitatively (C) through the OxyBlot kit, as described in Materials and Methods B) Protein carbonyl content is significantly elevated in whole brain homogenates from Twi mice (n=5) compared to wild-type controls (n=6). C) Elevated protein carbonyls are apparent in all regions of the Twi brain, including cerebellum, cortex and brain stem. D) Protein carbonyl levels increase as mice age and are significantly increased by PND10. * = p<0.05, **** = p<0.001.