Fig. 1.

Flow-chart of patient selection and follow-up. AI = adrenal insufficiency. *pre-existent panhypopituitarism before or immediately after surgery (n = 12), pre-existent isolated severe adrenal insufficiency before surgery (n = 4) or very low basal serum cortisol concentrations (mean 10 nmol/L) during follow-up after surgery (n = 4). **basal serum cortisol levels > 550 nmol/L (n=12), normal urine cortisol levels (n=3), short follow-up between repeated surgery or additional radiotherapy (n = 2), and follow-up <1 year (n = 2) or unspecified reasons (n = 7), basal serum cortisol <110 nmol/L (n = 1)